Microreactor technologies are no longer in their infancy and their applications in many areas are steeply growing. The technology offers advantages to classical approaches by allowing miniaturization of structural features up to the microreactor regime. Most of the reactions and transformations carried out in such devices benefit from the physical properties of microreactors, such as enhanced mass and heat transfer, because of a very large surface-to-volume ratio, as well as regular flow profiles leading to improved yields with increased selectivities. Strict control over thermal or concentration gradients within the microreactor allows new methods to provide efficient chemical transformations with high space-time yields. The mixing of substrates and reagents can be performed under highly controlled conditions leading to improved protocols.
Such features have many direct consequences. Hazardous, toxic or environment unfriendly chemicals are generated only in small amounts, despite the overall output, due to continuous regime, could be comparable with standard large scale batch processes. The PhD topic focuses on the rational synthesis of selected fine chemicals from the field of pharmaceuticals, and on the performance of the corresponding reactions in the microfludic chip reactor as a part of the microfluidic platform. Beta-ketoesters will be hydrogenated in the stereoselective mode, in fully green solvents ionic liquids, over noble metal chiral catalysts, to obtain optically pure products. Practical implementation save organic solvents, does not require the EIA process, inhibits any possible exposure to toxic chemicals, has zero negative impact on the environment, etc.
P. Kluson, P. Stavarek, V. Penkavova, H. Vychodilova, S. Hejda, M. Bendova: Microfluidic chip reactor and the stereoselective hydrogenation of MAA over Ru-BINAP in the [N8222][Tf2N] – methanol – water mixed phase, Chem. Eng. Proc. 115, 39 (2017).
P. Kluson, P. Stavarek, S. Hejda, V. Penkavova, M. Bendova, H. Vychodilova, D. Vlcek: Molecular structure effects of [NR,222][Tf2N] ionic liquids on their flow properties in the microfluidic chip reactor – a complete validation study, Chem. Eng. Proc. 111, 57 (2017).
D. N. Tito, P. Kluson: Amperometric analysis of Ru π – conjugated polymers: prospective co-supports for enantioselective Ru catalysts, J. Phys. Chem. C 120, 21228-21234 (2016).
P. Kluson P. Krystynik, P. Dytrych, L. Bartek: Interactions of the (R) Ru-BINAP catalytic complex with an inorganic matrix in stereoselective hydrogenation of methylacetoacetate: kinetic, XPS and DRIFT studies, Rect. Kinet. Mechan. Catal. 119, 393 (2016).
S. Hejda, M. Drhova, J. Kristal, D. Buzek, P. Krystynik, P. Kluson: Microreactor as efficient tool for light induced oxidation reactions, Chem. Eng. J. 255, 178 (2014).
Continual micro technologies for standard processes – GAMA 840209, Technology Agency of the Czech Republic
Deadline is closed